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KMID : 1237720220550010020
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Anatomy & Cell Biology
2022 Volume.55 No. 1 p.20 ~ p.27
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Blood-retina barrier dysfunction in experimental autoimmune uveitis: the pathogenesis and therapeutic targets
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Kim Jeong-Tae
Chun Ji-Yoon
Ahn Mee-Jung
Jung Kyung-Sook
Moon Chang-Jong
Shin Tae-Kyun
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Abstract
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Experimental autoimmune uveitis (EAU), an animal model of human uveitis, is characterized by infiltration of autoimmune T cells in the uvea as well as in the retina of susceptible animals. EAU is induced by the immunization of uveitogenic antigens, including either retinal soluble-antigen or interphotoreceptor retinoid-binding proteins, in Lewis rats. The pathogenesis of EAU in rats involves the proliferation of autoimmune T cells in peripheral lymphoid tissues and breakdown of the blood-retinal barrier, primarily in the uvea and retina, finally inducing visual dysfunction. In this review, we describe recent EAU studies to facilitate the design of a therapeutic strategy through the interruption of uveitogenic factors during the course of EAU, which will be helpful for controlling human uveitis.
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KEYWORD
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Autoimmunity, Blood-retina barrier, Experimental autoimmune uveitis, Interphotoreceptor retinoid-binding protein, Retinal soluble antigen
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